Approvals: Notices of Compliance
38,130 Notices of Compliance in Health Canada’s database. A Notice of Compliance (NOC) is Health Canada’s approval of a drug submission: a new drug, a generic, a new use, strength or form, or a change to an approved product. Natural health products and medical devices are licensed separately.
By year
New active substances (NAS) are drugs whose medicinal ingredient was never approved in Canada before.
| Year | Count |
|---|---|
| 2026 | 1,76932 new active substances |
| 2025 | 1,99846 new active substances |
| 2024 | 2,16529 new active substances |
| 2023 | 2,62042 new active substances |
| 2022 | 2,45046 new active substances |
| 2021 | 2,37243 new active substances |
| 2020 | 1,81936 new active substances |
| 2019 | 1,37135 new active substances |
| 2018 | 1,46140 new active substances |
| 2017 | 1,38736 new active substances |
| 2016 | 1,17138 new active substances |
| 2015 | 1,15137 new active substances |
| 2014 | 1,38427 new active substances |
| 2013 | 1,11440 new active substances |
| 2012 | 1,07523 new active substances |
| 2011 | 91727 new active substances |
| 2010 | 1,08722 new active substances |
| 2009 | 91128 new active substances |
| 2008 | 70518 new active substances |
| 2007 | 77024 new active substances |
| 2006 | 82123 new active substances |
| 2005 | 62324 new active substances |
| 2004 | 63629 new active substances |
| 2003 | 62320 new active substances |
| 2002 | 59024 new active substances |
| 2001 | 70327 new active substances |
| 2000 | 64726 new active substances |
| 1999 | 48337 new active substances |
| 1998 | 70730 new active substances |
| 1997 | 75642 new active substances |
| 1996 | 65535 new active substances |
| 1995 | 56729 new active substances |
| 1994 | 62225 new active substances |
Latest notices
- JAMP IBUPROFENOctober 9, 2026 · NOC 38451 · Abbreviated New Drug Submission (ANDS) · JAMP Pharma Corporation
- CARVYKTIOctober 9, 2026 · NOC 38450 · Supplement to a New Drug Submission (SNDS) · Janssen Inc.
- VIGAMOXOctober 9, 2026 · NOC 38449 · Supplement to a New Drug Submission (SNDS) · Novartis Pharmaceuticals Canada Inc.
- RAMIPRIL CAPSULESOctober 9, 2026 · NOC 38448 · Abbreviated New Drug Submission (ANDS) · Sanis Health Inc.
- NEURAXPHARM-MODAFINILOctober 9, 2026 · NOC 38447 · New Drug Submission (NDS) · Neuraxpharm Pharmaceuticals, S.L.
- CYKLOKAPRONOctober 9, 2026 · NOC 38446 · Supplement to a New Drug Submission (SNDS) · Pfizer Canada Ulc
- XOLAIROctober 9, 2026 · NOC 38445 · Supplement to a New Drug Submission (SNDS) · Novartis Pharmaceuticals Canada Inc.
- VFENDOctober 9, 2026 · NOC 38444 · Supplement to a New Drug Submission (SNDS) · Pfizer Canada Ulc
- LEUCOVORIN CALCIUM INJECTIONOctober 9, 2026 · NOC 38443 · Supplement to a New Drug Submission (SNDS) · Teva Canada Limited
- DOXYCIN CAPSULES; DOXYCIN TABLETSOctober 9, 2026 · NOC 38442 · Supplement to a New Drug Submission (SNDS) · Laboratoire Riva Inc.
- RIVA SITAGLIPTINOctober 9, 2026 · NOC 38441 · Abbreviated New Drug Submission (ANDS) · Laboratoire Riva Inc.
- JAMP ELTROMBOPAGOctober 9, 2026 · NOC 38440 · Abbreviated New Drug Submission (ANDS) · JAMP Pharma Corporation
- NALOXONE HYDROCHLORIDE INJECTIONOctober 9, 2026 · NOC 38439 · Abbreviated New Drug Submission (ANDS) · Juno Pharma Canada Inc.
- PEGYLATED LIPOSOMAL DOXORUBICIN HYDROCHLORIDE FOR INJECTIONOctober 9, 2026 · NOC 38437 · Supplement to an Abbreviated New Drug Submission (SANDS) · Dr Reddys Laboratories Ltd
- PMS-LOXAPINEOctober 9, 2026 · NOC 38436 · New Drug Submission (NDS) · Pharmascience Inc.
- LABETALOL HYDROCHLORIDE INJECTIONOctober 9, 2026 · NOC 38435 · Abbreviated New Drug Submission (ANDS) · Juno Pharma Canada Inc.
- AURO-MYCOPHENOLIC ACIDOctober 8, 2026 · NOC 38453 · Abbreviated New Drug Submission (ANDS) · Auro Pharma Inc.
- GLN-METFORMIN XROctober 8, 2026 · NOC 38452 · Abbreviated New Drug Submission (ANDS) · Glenmark Pharmaceuticals Canada Inc.
- SANDOZ CANDESARTAN PLUSOctober 8, 2026 · NOC 38438 · Supplement to an Abbreviated New Drug Submission (SANDS) · Sandoz Canada Inc.
- MINT-LEVODOPA/BENSERAZIDEOctober 8, 2026 · NOC 38434 · Abbreviated New Drug Submission (ANDS) · Mint Pharmaceuticals Inc
- OCZYESA XROctober 8, 2026 · NOC 38433 · New Drug Submission (NDS) · Camurus Ab
- YORVIPATHOctober 8, 2026 · NOC 38432 · Supplement to a New Drug Submission (SNDS) · Pendopharm Division Of Pharmascience Inc
- ACTONEL; ACTONEL DROctober 8, 2026 · NOC 38431 · Supplement to a New Drug Submission (SNDS) · AbbVie Corporation
- JASCAYDOctober 8, 2026 · NOC 38430 · New Drug Submission (NDS) · Boehringer Ingelheim (Canada) Ltd.
- SPC-ROSUVASTATINOctober 8, 2026 · NOC 38428 · Supplement to an Abbreviated New Drug Submission (SANDS) · Sun Pharma Canada Inc.
- MYCOPHENOLATE MOFETILOctober 8, 2026 · NOC 38427 · Supplement to an Abbreviated New Drug Submission (SANDS) · Sivem Pharmaceuticals Ulc
- SEPHIENCEOctober 7, 2026 · NOC 38429 · Supplement to a New Drug Submission (SNDS) · Ptc Therapeutics International Limited
- SANDOZ DORZOLAMIDE/TIMOLOLOctober 7, 2026 · NOC 38426 · Supplement to an Abbreviated New Drug Submission (SANDS) · Sandoz Canada Inc.
- TEVA-SALBUTAMOL HFAOctober 7, 2026 · NOC 38425 · Supplement to a New Drug Submission (SNDS) · Teva Canada Limited
- TOBI PODHALEROctober 7, 2026 · NOC 38424 · Supplement to a New Drug Submission (SNDS) · BGP Pharma ULC
- DUAKLIR GENUAIROctober 7, 2026 · NOC 38423 · New Drug Submission (NDS) · Azurity Pharmaceuticals Ireland Limited
- PRO-METOPROLOL; PRO-METOPROLOL-LOctober 7, 2026 · NOC 38422 · Supplement to a New Drug Submission (SNDS) · Pro Doc Limitee
- CAPRELSAOctober 7, 2026 · NOC 38421 · New Drug Submission (NDS) · Esteve Pharmaceuticals S.A.
- BILASTINEOctober 6, 2026 · NOC 38419 · Abbreviated New Drug Submission (ANDS) · Sanis Health Inc.
- TYSABRIOctober 6, 2026 · NOC 38418 · Supplement to a New Drug Submission (SNDS) · Biogen Canada Inc
- CISATRACURIUM BESYLATE INJECTION USP MULTIDOSE; CISATRACURIUM SINGLE DOSEOctober 6, 2026 · NOC 38417 · Abbreviated New Drug Submission (ANDS) · Juno Pharma Canada Inc.
- XYNTHA SOLOFUSEOctober 6, 2026 · NOC 38416 · Supplement to a New Drug Submission (SNDS) · Pfizer Canada Ulc
- DUPIXENTOctober 6, 2026 · NOC 38414 · Supplement to a New Drug Submission (SNDS) · Sanofi-Aventis Canada Inc.
- ANDEMBRYOctober 6, 2026 · NOC 38413 · Supplement to a New Drug Submission (SNDS) · Csl Behring Canada Inc
- PMS-DICLOFENACOctober 6, 2026 · NOC 38411 · Supplement to an Abbreviated New Drug Submission (SANDS) · Pharmascience Inc.
- JAMP ELAGOLIXOctober 6, 2026 · NOC 38410 · Abbreviated New Drug Submission (ANDS) · JAMP Pharma Corporation
- DIASTATOctober 5, 2026 · NOC 38415 · Supplement to a New Drug Submission (SNDS) · Bausch Health, Canada Inc.
- SANDOZ METFORMIN FCOctober 5, 2026 · NOC 38412 · Supplement to an Abbreviated New Drug Submission (SANDS) · Sandoz Canada Inc.
- PRO-NAPROXEN; PRO-NAPROXEN ECOctober 5, 2026 · NOC 38409 · Supplement to a New Drug Submission (SNDS) · Pro Doc Limitee
- NRA-DULOXETINEOctober 5, 2026 · NOC 38407 · Supplement to an Abbreviated New Drug Submission (SANDS) · Nora Pharma Inc.
- NB-DULOXETINEOctober 5, 2026 · NOC 38403 · Supplement to an Abbreviated New Drug Submission (SANDS) · NB Pharma Inc.
- FREHEMGOOctober 2, 2026 · NOC 38420 · New Drug Submission (NDS) · Novo Nordisk Canada Inc
- DARZALEX SCOctober 2, 2026 · NOC 38408 · Supplement to a New Drug Submission (SNDS) · Janssen Inc.
- OLMESARTAN MEDOXOMIL / HYDROCHLOROTHIAZIDEOctober 2, 2026 · NOC 38406 · Supplement to an Abbreviated New Drug Submission (SANDS) · Jubilant Generics Limited
- VOXZOGOOctober 2, 2026 · NOC 38405 · Supplement to a New Drug Submission (SNDS) · Biomarin International Limited
- WEGOVYOctober 2, 2026 · NOC 38404 · Supplement to a New Drug Submission (SNDS) · Novo Nordisk Canada Inc
- AURO-ATOVAQUONEOctober 2, 2026 · NOC 38402 · Supplement to an Abbreviated New Drug Submission (SANDS) · Auro Pharma Inc.
- APO-MYCOPHENOLIC ACIDOctober 2, 2026 · NOC 38400 · Supplement to an Abbreviated New Drug Submission (SANDS) · Apotex Inc.
- EZETIMIBEOctober 2, 2026 · NOC 38398 · Abbreviated New Drug Submission (ANDS) · Sanis Health Inc.
- ALLEGRA 12 HOUR; ALLEGRA 24 HOUR; ALLEGRA HIVESOctober 2, 2026 · NOC 38392 · New Drug Submission (NDS) · Opella Canada Inc.
- ZEJULAOctober 1, 2026 · NOC 38401 · Supplement to a New Drug Submission (SNDS) · Glaxosmithkline Inc
- DONEPEZIL HYDROCHLORIDEOctober 1, 2026 · NOC 38399 · Supplement to an Abbreviated New Drug Submission (SANDS) · Jubilant Generics Limited
- ACTIFEMME LDOctober 1, 2026 · NOC 38397 · Abbreviated New Drug Submission (ANDS) · Novast Laboratories Ltd.
- TEVA-RISEDRONATEOctober 1, 2026 · NOC 38395 · Supplement to an Abbreviated New Drug Submission (SANDS) · Teva Canada Limited
- AURO-HYDROXYCHLOROQUINEOctober 1, 2026 · NOC 38394 · Abbreviated New Drug Submission (ANDS) · Auro Pharma Inc.